FEATURE ARTICLE Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model
نویسندگان
چکیده
Department of Physics, Yale University, New Haven, CT 06520, USA, Department of Neurobiology, Kavli Institute of Neuroscience, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Center for the Translational Neuroscience of Alcoholism (CTNA), Department of Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University, New Haven, CT 06519, USA, Psychiatry Services, Department of Psychiatry, Yale-New Haven Hospital, New Haven, CT, USA, Division of Clinical Neuroscience, Veterans Affairs (VA) National Center for Post-Traumatic Stress Disorder (PTSD), VA Connecticut Healthcare System, West Haven, CT 06516, USA and Center for Neural Science, New York University, New York, NY 10003, USA
منابع مشابه
Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model.
Excitation-inhibition balance (E/I balance) is a fundamental property of cortical microcircuitry. Disruption of E/I balance in prefrontal cortex is hypothesized to underlie cognitive deficits observed in neuropsychiatric illnesses such as schizophrenia. To elucidate the link between these phenomena, we incorporated synaptic disinhibition, via N-methyl-D-aspartate receptor perturbation on intern...
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Schizophrenia is associated with severe cognitive deficits, including impaired working memory (WM). A neural mechanism that may contribute to WM impairment is the disruption in excitation-inhibition (E/I) balance in cortical microcircuits. It remains unknown, however, how these alterations map onto quantifiable behavioral deficits in patients. Based on predictions from a validated microcircuit ...
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